Endocrine Abstracts

Background and aims: To assess the prevalence and variability of pathogenic or likely pathogenic autosomal dominant mutations (ADM) of Familial Hypercholesterolemia (FH) in a Finnish cohort of patients with premature coronary artery disease (CAD) and elevated LDL-C levels.Methods: Study population was enrolled from 162 patients diagnosed with premature CAD (men < 55 years and women < 60 years) and history of high LDL-C (≥ 5 mmol/l) levels, ...

Objectives: The variability of thyroid hormone levels during long-term antithyroid drug (ATD) therapy and its possible association with adverse health outcomes has not been previously studied. The aim of this study was to evaluate the association of thyroid function test (TFT) variability and cardiovascular disease (CVD) morbidity during long-term ATD therapy. Furthermore, clinical factors related to high TFT variability during the ATD therapy were identified.<p class="abs...

Familial hypercholesterolemia (FH) remains underdiagnosed in general population. Screening programs in unselected individuals have shown modest results in identifying patients with FH. Incidence of FH is higher in young patients with coronary artery disease (CAD), especially when associated with high LDL-cholesterol levels. Targeted screening in this population could add value to FH-index patient identification. We have established an IT-based automated screening tool to enhan...

Introduction and design: Parathyroid carcinoma (PC) is a rare endocrine malignancy and the diagnosis is difficult. As the incidence seems to be increasing, we examined all cases diagnosed in our country during years 2000–2011 and compared the results to those of atypical parathyroid (AA; n=28) and parathyroid adenomas (A; n=72). All tissue specimens were re-examined.Results: In 2000–2011, 32 patients were diagnosed with PC in ...

IntroductionInsulinomas are the most common functional neuroendocrine tumours of the pancreas. Because previous data on the long-term prognosis of insulinoma patients are scarce, we wanted to study the morbidity and mortality in Finnish patients previously treated for an insulinoma.Patients and methodsThe Finnish insulinoma register consists of all adult patients diagnosed with an insulinoma in Finland during...